A VR View: Severe Uncontrolled Asthma: Phenotypes, Endotypes, and Treatment Response Decisions

Friday, November 08, 2019
8:15 PM – 9:15 PM


Hilton Americas-Houston
1600 Lamar St,
Houston, TX 77010
Meeting Room: Ballroom of the Americas Salons D and E


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Friday, November 08, 2019

09:15 PM Eastern    08:15 PM Central    07:15 PM Mountain    06:15 PM Pacific

Add to Calendar 11/08/2019 09:15 PM 11/08/2019 10:15 PM America/New_York A VR View: Severe Uncontrolled Asthma: Phenotypes, Endotypes, and Treatment Response Decisions A VR View: Severe Uncontrolled Asthma: Phenotypes, Endotypes, and Treatment Response Decisions Live Simulcast Med Learning Group info@medlearninggroup.com false MM/DD/YYYY atZOdzeAgzXtBkKLjmOo27579



  • VIRTUAL REALITY SETS provided to all attendees for viewing this presentation only
  • Interactive, case-based learning environment
  • Create your own personalized poster
  • iPads provided to enhance learning experience and enable real-time Q&A


Michael E. Wechsler, MD, MMSc
Director, The Cohen Family Asthma Institute
Department of Medicine
Division of Pulmonary, Critical Care and Sleep Medicine
National Jewish Health
Denver, CO


After completing the educational activity, learners should be better able to:

  • Review how the varying inflammatory profiles of the different asthma phenotypes can inform the development of new treatments for severe uncontrolled asthma
  • Evaluate the usefulness of phenotypic- or endotypic-specific biomarkers in diagnosing, classifying, and controlling severe uncontrolled asthma
  • Develop treatment plans individualized for each patient with severe asthma accounting for specific patient factors, current evidence-based guidance, and the clinical profiles of current treatments


I. Introduction

II. Pathogenesis Primer for Asthma
  A. Review of molecular involvement in asthma inflammation and type 2 immune processes
    • Severe phenotypes – atopic and non-atopic
       – Variable clinical, molecular, and immunologic features
       – IgE, FeNO, eosinophilia, and comorbidities
  B. VR Animation: a view of immune cells, inflammatory cytokines, and the process resulting in the underlying pathology of asthma with nasal mucosal cross-talk

III. Diagnosis of Asthma
  A. Guidelines establishing diagnosis and associated comorbidities
  B. Diagnostic testing methods
  C. Differentiating between other chronic respiratory conditions
  D. Asthma phenotypes/subtypes and implications for treatment

IV. Asthma Treatment for Moderate to Severe Disease
  A. Goals of treatment: achieving disease control, preventing exacerbations, reducing morbidity and mortality
  B. Pharmacologic treatment options and monitoring response
    • Biological targeted monoclonal antibodies – clinical trials data (omalizumab, mepolizumab, reslizumab, and benralizumab)
    • Type 2 biomarkers – utility and interpretation
    • Decreased exacerbations and daily corticosteroid dose, improved lung function (FEV1)
  C. Recent data on targeted therapies
    • Dupilumab – efficacy and safety data in moderate to severe asthma
    • VR Animation: current inflammatory targets for severe asthma and mechanisms of action of monoclonal antibodies for IgE, IL-4, IL-5, and IL-13

V. Conclusions

VI. Questions and Answers


This initiative is designed to meet the educational needs of pulmonologists, allergists, immunologists, ENTs and primary care physicians who are involved in the healthcare of patients with moderate-to-severe asthma.


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