Utilizing the Molecular/Physiologic Phenotype to Direct Asthma Therapy: A Comprehensive 3-Dimensional Study
6:30 PM – 8:00 PM
Sheraton Seattle Hotel
1400 6th Ave, Seattle, WA 98101
Meeting Room: Salon B – 3rd FL
In conjunction with the 2018 ACAAI Annual Meeting
Thursday, November 15, 2018
9:30 PM Eastern 8:30 PM Central 7:30 PM Mountain 6:30 PM Pacific
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Jonathan Corren, MD
Director Allergy Medical Center
Associate Professor Department of Internal Medicine
UCLA Medical Center
Los Angeles, CA
Michael E. Wechsler, MD, MMSc
Director, Asthma Program
Department of Medicine
Division of Pulmonary, Critical Care and Sleep Medicine
National Jewish Health
I. Severe asthma: Standard definitions, increased understanding of the molecular biology of inflammation, and a changing paradigm
a. Evolving concepts of asthma as a heterogeneous condition
b. Pathophysiology: Variation among causative factors, cells, and cell mediators
II. Basic pathology of type 2 and non-type 2 asthma
a. Cellular phenotypes
c. How to assess characteristics in practical clinic setting
III. How endotype and phenotype informs/will inform treatment decisions and lead to personalized treatment therapy
IV. Treatment guidelines: The “one size fits all” treatment guidelines vs nuances of genome
V. Approved therapies
• Biomarkers and targeted therapies:
VI. Approved procedure: Bronchial thermoplasty
VII. Potential therapies
After completing the CME activity, learners should be better able to:
- Assess the causes of underlying inflammation in asthma, and resulting targets of therapy
- Evaluate the level of asthma control, disease severity, and exacerbation risk to better drive appropriate treatment
- Review currently-available and novel targeted therapies and their effect on treatment strategies for patients with moderate-to-severe asthma
This CME initiative is designed to meet the educational needs of pulmonologists, allergists, immunologists and primary care physicians who are involved in the healthcare of patients with severe asthma.
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